METHOD OF EXTENSIVE CULTURE OF ANTIGEN-SPECIFIC CYTOTOXIC T CELLS

摘要

A method of inducing, maintaining and extensively culturing CTLs (cytotoxic T cells), which sustain an antigen-specific cytotoxicity at a high level and are appropriately usable in adoptive immunotherapy, by using at least one compound selected from the group consisting of acidic polysaccharides, acidic oligosaccharides, acidic monosaccharides and salts thereof as the active ingredient. Examples of the above-described compound include fucoidan, heparin, alginic acid, chondroitin sulfate A, chondroitin sulfate B, pectic acid, hyaluronic acid, fucoidan degradation products, sulfated glucose, sulfated fucose and salts thereof.