PPAR delta ACTIVATORS

摘要

Compounds of the general formula (¦) or salts thereof; and activators of PPAR delta (peroxisome proliferator activated receptor delta ) containing the compounds or the salts as the active ingredient: (I) wherein R<1> and R<2> are each hydrogen, C1-8 alkyl, an aryl or heterocyclic group which may be substituted, or the like; A is oxygen, sulfur, or the like; X<1> and X<2> are each a free valency, oxygen, S(O)p (wherein p is an integer of 0 to 2), C(=O), C(=O)NH, NHC(=O), CH=CH, or the like; Y is optionally substituted C1-8 alkylene; Z is oxygen or sulfur; R<3> and R<4> are each optionally substituted C1-8 alkyl; and R<8> is hydrogen or C1-8 alkyl, with the proviso that when X<1> is a free valency, X<2> is not O or S(O)p, while when X<1> is C(=O)NH, X<2> is not a free valency.