发明名称 |
Human RRP sequences and methods of use |
摘要 |
Rhomboid Related Proteins (RRPs), involved in the EGFR signaling pathway, are provided. Transgenic, nonhuman mammals containing a transgene encoding an RRP polypeptide or a gene effecting the expression of an RRP polypeptide, along with methods of modulating the interaction of RRP proteins with their pathway members, and methods of screening for agents that modulate the interaction of an RRP polypeptide with an RRP binding target, such as RRP-specific antibodies and small molecules identified in high throughput screens, are also provided. Modulating agents identified using the methods of the invention can be used to specifically inhibit growth of tumor cells that overexpress an RRP protein.
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申请公布号 |
US2002022029(A1) |
申请公布日期 |
2002.02.21 |
申请号 |
US20010908419 |
申请日期 |
2001.07.18 |
申请人 |
LIOUBIN MARIO N.;FRIEDMAN LORI;BELVIN MARCIA;LARSON JEFFERY S.;CHEN CHANGYOU;ROBERSTON STEPHANIE A.;SHI WEN;CHAN JOCELYN;LI DANXI |
发明人 |
LIOUBIN MARIO N.;FRIEDMAN LORI;BELVIN MARCIA;LARSON JEFFERY S.;CHEN CHANGYOU;ROBERSTON STEPHANIE A.;SHI WEN;CHAN JOCELYN;LI DANXI |
分类号 |
C12N15/09;A61K38/00;A61K39/395;A61K45/00;A61K48/00;A61P35/00;C07K14/47;C07K14/705;C12N1/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12P21/02;(IPC1-7):G01N33/574;C07H21/04;C12N5/06 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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