发明名称 |
2,4-SUBSTITUTED PYRIDINE DERIVATIVES |
摘要 |
Disclosed are compounds of the formula (I) or pharmaceutically acceptable salts thereof wherein: (i) represents: (ii, iii, iv, v) and A, B, G, D, E, Ra, Rb, W, and Z are defined herein. These compounds are agonists, antagonists or inverse agonists for GABAA brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAA brain receptors and are therefore useful in the diagnosis and treatment of anxiety, depression, down Syndrome, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory. Pharmaceutical compositions, including packaged pharmaceutical compositions, are further provided. Compounds of the invention are also useful as probes for the localization of GABAA receptors in tissue samples. |
申请公布号 |
WO0214269(A2) |
申请公布日期 |
2002.02.21 |
申请号 |
WO2001US41757 |
申请日期 |
2001.08.16 |
申请人 |
NEUROGEN CORPORATION;CAI, GUOLIN;ALBAUGH, PAMELA;YUAN, JUN;CURRIE, KEVIN, S.;HUTCHISON, ALAN |
发明人 |
CAI, GUOLIN;ALBAUGH, PAMELA;YUAN, JUN;CURRIE, KEVIN, S.;HUTCHISON, ALAN |
分类号 |
A61K31/4365;A61K31/4375;A61K31/4709;A61K31/496;A61K31/551;A61P9/00;A61P9/10;A61P25/00;A61P25/16;A61P25/18;A61P25/20;A61P25/22;A61P25/24;A61P25/28;A61P43/00;C07D215/52;C07D401/06;C07D401/12;C07D401/14;C07D409/04;C07D409/14;C07D471/04;C07D495/04;C07D521/00 |
主分类号 |
A61K31/4365 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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