发明名称 |
REMEDIES FOR KIDNEY DISEASES AND METHOD FOR SCREENING THE SAME |
摘要 |
<p>The present invention provides a method for screening or identifying therapeutic or prophylactic agents for renal diseases, which comprises assaying a test substance for the activity of up-regulating the expression of fatty acid-binding protein (FABP), and novel mouse proximal renal tubular epithelial cell lines useful therein. The present invention also provides therapeutic or prophylactic agents for renal diseases comprising, as an active ingredient, an agent having activity of up-regulating FABP expression; agents for up-regulating the expression of FABP, and for treating or preventing renal diseases, which comprise a compound having activity of peroxisome proliferator-activated receptor (PPAR) agonist or carnitine palmitoyltransferase (CPT) inhibitor or the like.</p> |
申请公布号 |
EP1180686(A1) |
申请公布日期 |
2002.02.20 |
申请号 |
EP20000909752 |
申请日期 |
2000.03.21 |
申请人 |
TANABE SEIYAKU CO., LTD. |
发明人 |
YAMANOUCHI, MASAYA;HASE, HIROMI;HONDA, AKIKO;SUGAYA, TAKESHI |
分类号 |
A01K67/027;A61K31/00;A61K31/336;A61K31/41;A61K31/425;A61K31/4439;A61K38/00;C07K14/475;C07K14/705;C12N5/071;C12N15/85;C12Q1/68;G01N33/92;(IPC1-7):G01N33/50;C12N15/12;C12N5/10;C12N5/16;A61K45/00;A61K31/426;G01N33/15 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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