发明名称 |
MOLECULAR CHARACTERISATION OF CHROMOSOME TRANSLOCATION t(11;18)(q21;q21) AND ITS CORRELATION TO CARCINOGENESIS |
摘要 |
<p>The invention discloses means and methods for determining whether a tissue sample or an analogue and/or derivative thereof comprises a cell with a chromosome {11:18} translocation associated with malignancies such as mucosa-associated lymphoid tissue (MALT) lymphoma's. The invention further provides insight into a novel mechanism of transformation of primary cells. Said mechanism involving expression of a fusion proteinaceous molecule comprising at least apoptosis inhibitor 2 (API2) or a functional part, derivative and/or analogue thereof fused to at least one other proteinaceous molecule. The invention also provides a novel nucleic acid sequence and proteinaceous molecule expressed from said sequence termed MALT-lymphoma associated Translocation (MLT) protein.</p> |
申请公布号 |
EP1180168(A1) |
申请公布日期 |
2002.02.20 |
申请号 |
EP20000938685 |
申请日期 |
2000.05.26 |
申请人 |
VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW. |
发明人 |
BAENS, MATTHIJS;MARYNEN, PETER;DIERLAMM, JUDITH |
分类号 |
A01K67/027;A61K39/00;A61K48/00;C07K14/47;C07K19/00;C12N5/10;C12Q1/68;(IPC1-7):C12Q1/68 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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