发明名称 |
CYCLIC AMIDE COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF |
摘要 |
<p>A compound of the formula: <CHEM> wherein R<1> is a hydrocarbon group, R<2> is a hydrocarbon group having 2 or more carbon atoms, where R<1> and R<2> may in combination form, together with an adjacent nitrogen atom, a ring optionally having a substituent or substituents, R<3> is a hydrocarbon group optionally having a substituent or substituents or a heterocyclic group optionally having a substituent or substituents, R<4> is a hydrogen atom, a hydrocarbon group, a heterocyclic group and the like, E is a divalent chain hydrocarbon group and the like, G is CO or SO2, J is a nitrogen atom, a methine group and the like, and Q and R are each a divalent chain C1-3 hydrocarbon group and the like, and a salt thereof show a superior CCR5 antagonistic activity and are useful as agents for the prophylaxis or treatment of HIV infection of human peripheral blood mononuclear cells, particularly AIDS.</p> |
申请公布号 |
EP1180513(A1) |
申请公布日期 |
2002.02.20 |
申请号 |
EP20000921055 |
申请日期 |
2000.04.27 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
ISHIHARA, YUJI;IMAMURA, SHINICHI;HASHIGUCHI, SHOHEI;NISHIMURA, OSAMU;KANZAKI, NAOYUKI;BABA, MASANORI |
分类号 |
C07D207/277;A61P31/18;A61P43/00;C07D207/26;C07D211/18;C07D211/26;C07D211/32;C07D211/52;C07D211/78;C07D265/30;C07D401/06;C07D401/12;C07D401/14;C07D403/12;C07D405/06;C07D405/12;C07D405/14;C07D413/14;(IPC1-7):C07D207/277;A61K31/454;A61K31/401;C07D413/06;C07D403/06;A61K31/537;A61K31/55;A61K31/496 |
主分类号 |
C07D207/277 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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