Prevention of beta-amyloid neurotoxicity by blockade of the ubiquitin-proteasome proteolytic pathway

摘要

Compositions and methods for inhibiting neurotoxic ubiquitin-proteasome proteolysis, and treatment of neurodegenerative disorders. In particular, a method of suppressing the neurotoxic effect of beta -amyloid peptide, by administering an inhibitor to block beta -amyloid peptide-mediated ubiquitin-proteasome proteolysis. Preferred inhibitors are inhibitors of ubiquitination, such as leucine-alanine dipeptide, and inhibitors of post-ubiquitination proteasome activity, such as lactacystin.