Benzimidazole derivatives, preparation and therapeutic use thereof

摘要

The invention relates to benzimidazole derivatives of general formulain whichX represents a nitrogen atom or a carbon atom;and when X represents a nitrogen atom:R3 represents a hydrogen atom or a C1-C4 alkyl group, or does not exist, to give the compounds of formula (I) comprising a secondary or tertiary amine;R4 represents a hydrogen atom or a C1-C6 alkyl, C3-C7 cycloalkyl, optionally substituted C3-C7 heterocycloalkyl, -(CH2)p-heteroaryl, heteroaryl-carbonyl, phenylcarbonyl, (C1-C6)alkylcarbonyl, -(CH2)pCOOR, optionally substituted phenylsulphonyl or optionally substituted -(CH2)p-phenyl group,and, when X represents a carbon atom:R3 represents a hydrogen atom or a group -NR5R6, -N(R5)3<+>, -NHCOR7, -CONHR5, -COR7, -NHCONH2, -OH or -CH2OH,R4 represents a hydrogen atom or an optionally substituted -(CH2)p-phenyl, -(CH2)p-heteroaryl or -(CH2)tNR7R8 group.Preparation process and therapeutic application.