1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS

摘要

The present invention relates to compounds of formula (I) wherein each A is independently halo; Y is (CH2)m-, -C(O)- or S(O)-; R<1> and R<2> are independently C1-4 alkyl; R<3> is substituted azacycloalkyl etc.; R<4> is phenyl substituted at the 2-position with a substituent selected from substituted C1-7 alkyl, substituted C1-7 alkyl, substituted C1-7 alkoxy, amine, etc; R<5> is hydrogen or C1-4 alkyl; m is 0, 1 or 2; and n is 0, 1, 2, 3, 4 or 5. The present invention also relates to pharmaceutical compositions containing such compounds and to the use of such compounds in the treatment and prevention of inflammation, asthma, allergic rhinitis, pain and other disorders.