The present invention is based in part on the surprising discovery that Tanshinones from <i>Salvia miltiorrhiza</i> act as allosteric high-potency <i>N</i>-methyl-D-aspartate receptor antagonists. Pharmacological blockade of excessive activation of <i>N</i>-methyl-D-aspartate receptors (NMDARs) greatly reduces ischemic injury of neurons in cell culture and animal models. Tanshinones thus represent a novel class of compounds with NMDA receptor blocking activities with potential for the development of safe neuroprotective drugs for therapy of stroke and other neurodegenerative and neuropsychiatric disorders.
申请公布号
WO0212218(A1)
申请公布日期
2002.02.14
申请号
WO2001US24435
申请日期
2001.08.03
申请人
HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY;SUCHER, NIKOLAUS, J.;GONG, XIANDI;CARLES, MARIA;IP, NANCY;CHEN, FENG