| 摘要 |
<p>Polypeptides capable of binding to PtdIns(3,4)P2, PtdIns3P, PtdIns4P or PtdIns(3,5)P2 but not capable of binding to PtdIns(3,4,5)P3, in a screening method for identifying a compound suitable for modulating signalling by PtdIns(3,4)P2, PtdIns3P, PtdIns4P or PtdIns(3,5)P2. The polypeptides preferably comprises a PH (pleckstrin homology) domain which binds specifically to one of PtdIns(3,4)P2, PtdIns3P, PtdIns4P or PtdIns(3,5)P2. The PH domain preferably has at least five of the six residues of a Putative PtdIns(3,4,5)P3 Binding Motif (PPBM).</p> |
