摘要 |
This invention provides a class of therapeutic compounds and methods for the treatment of mammals with physiological disorders, such as for example a frequently occurring type of essential hypertension, which are critically associated with the decreased binding of magnesium to the plasma membranes o f their cells. These methods consist of administering to a mammal in need of such treatment a compound selected from a series of distributed trans, trans 1,3-butadienes, 1, 3-disubstituted perhydrobutadienes, 1,2-disubstituted tra ns ethylenes and 1,2-disubstituted ethanes and disubstituted propanes, each of which embodies, in common, the unique structural feature essential for the biological activity if these compounds. This invention also provides for pharmaceutical formulations that employ these novel compounds.
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