INHALEABLE SPRAY DRIED 4-HELIX BUNDLE PROTEIN POWDERS HAVINGMINIMIZED AGGREGATION
摘要
The present invention provides highly dispersible spray-dried powder compositions, and in particular, inhaleable dry powder compositions for aerosolized delivery o the lungs. The powders of the invention are produced by spray drying a 4 .alpha.-helix bundle protein under conditions which both: ( i) protect th eprotein from aggregation and (ii) provide particles suitable for inhalation (i.e., demonstrating superior aerosol performance).
申请公布号
CA2418960(A1)
申请公布日期
2002.02.14
申请号
CA20012418960
申请日期
2001.08.06
申请人
INHALE THERAPEUTIC SYSTEMS, INC.
发明人
GONG, DAVID;HASTEDT, JAYNE E.;STEVENSON, CYNTHIA;LEHRMAN, S. RUSS;CHIANG, HI-SHI;YANG, BING;CABOT, KIRSTEN;LESIKAR, DAVID;BENNETT, DAVID B.