17.BETA.-CARBOTHIOATE 17.ALPHA.-ARYLCARBONYLOXYLOXY ANDROSTANE DERIVATIVE AS ANTI-INFLAMMATORY AGENTS

摘要

There are provided according to the invention compounds of formula (I) where in R1 represents C1-6 alkyl or C1-6 haloalkyl; R2 represents -C(=O)-aryl or - C(=O)-heteroaryl; R3 represents hydrogen, methyl (which may be in either the .alpha. or .beta. configuration) or methylene; R4 and R5 are the same or different and each represents hydrogen or halogen; and ---- represents a single or a double bond; and salts and solvates thereof. There are also provided processes for preparing compounds of formula (I) and use of the compounds in therapy especially in the treatment of inflammatory and allergi c conditions.