| 发明名称 |
New isoxazole-sulfonamide endothelin antagonists |
| 摘要 |
Isoxazole-sulfonamide endothelin antagonists of formula (I) below having good affinity for endothelin receptors and selectivity for ETA over ETB are described herein. Such compounds are useful in the treatment of conditions mediated by endothelin, in particular, conditions mediated by endothelin ETA.
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| 申请公布号 |
US2002019408(A1) |
申请公布日期 |
2002.02.14 |
| 申请号 |
US20010867488 |
申请日期 |
2001.05.30 |
| 申请人 |
BANKS BERNARD JOSEPH;CHUBB NATHAN ANTHONY LOGAN;ESHELBY JAMES JOHN;PACEY MICHAEL STEPHEN;SCHULZ DARREN JOHN |
发明人 |
BANKS BERNARD JOSEPH;CHUBB NATHAN ANTHONY LOGAN;ESHELBY JAMES JOHN;PACEY MICHAEL STEPHEN;SCHULZ DARREN JOHN |
| 分类号 |
C07D231/52;C07D239/52;C07D239/69;C07D401/12;C07D403/12;C07D403/14;C07D405/04;C07D405/14;C07D409/04;C07D409/14;C07D413/14;(IPC1-7):C07D413/02;A61K31/42;A61K31/506;C07D261/06 |
主分类号 |
C07D231/52 |
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