发明名称 |
VACCINE FOR THE TREATMENT OF ARTHEROSCLEROSIS |
摘要 |
Novel vaccine therapies, and prophylactic treatments of atherosclerotic diseases involving use of immugones comprising apolipoproteins, or fragments thereof, having at least one of the following activities: (a) the inhibition of the binding of Apolipoprotein B to its receptor, and, or, (b) the inhibition of lipoprotein lipase. A preferred example of one such apolipoprotein is Apolipoprotein C-III (ApoCIII). The vaccines of the present invention, comprising said immunogens, prevent atheroslerosis plaque formation, thereby reducing coronary or cerebrovascular disease. Artherosclerosis is also treated by selectively inhibiting the activity of specific apolipoproteins e.g. ApoCIII in a human, comprising administering an agent which results in the selective inhibition of the apolipoprotein activity to a human. Atherosclerosis is also treated by active or passive vaccination, by administering an antibody that is capable of binding to a apoliprotein e.g. ApoCIII that has at least one of the following activities: (a) the inhibition of the binding of Apolipoprotein B to its receptor, and, or, (b) the inhibition of lipoprotein lipase.
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申请公布号 |
WO0164008(A3) |
申请公布日期 |
2002.02.14 |
申请号 |
WO2001EP02326 |
申请日期 |
2001.03.01 |
申请人 |
SMITHKLINE BEECHAM BIOLOGICALS S.A.;FRUCHART, JEAN-CHARLES;MONTEYNE, PHILIPPE;PALMANTIER, REMI;VAN MECHELEN, MARCELLE, PAULETTE |
发明人 |
FRUCHART, JEAN-CHARLES;MONTEYNE, PHILIPPE;PALMANTIER, REMI;VAN MECHELEN, MARCELLE, PAULETTE |
分类号 |
A61K45/00;A61K39/00;A61K39/395;A61P9/10;A61P43/00;C07K7/08;C07K14/47;(IPC1-7):A61K38/17 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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