发明名称 |
DRUG DELIVERY SYSTEM FOR ENHANCED BIOAVAILABILITY OF HYDROPHOBIC ACTIVE INGREDIENTS |
摘要 |
The present invention provides a drug delivery system for the oral administration of a hydrophobic active ingredient. The active ingredient's post ingestion dissolution rate and its corresponding bioavailability can be optimized by intimately mixing a micronized hydrophobic drug with suitably sized inert particles to a dispersion that will facilitate desired bioavailability. In a particular embodiment, the hydrophobic active ingredient is fenofibrate. Suitably sized inert particles include microcrystalline cellulose and lactose. Dispersion may be monitored by microscopic visualization.
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申请公布号 |
WO0211699(A1) |
申请公布日期 |
2002.02.14 |
申请号 |
WO2001US23401 |
申请日期 |
2001.07.26 |
申请人 |
IMPAX LABORATORIES, INC |
发明人 |
TENG, CHING-LING;HSIAO, CHARLES;GATTS, JOSHUA |
分类号 |
A61K9/14;A61K9/26;(IPC1-7):A61K9/14;A61K9/20;A61K9/48 |
主分类号 |
A61K9/14 |
代理机构 |
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主权项 |
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地址 |
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