| 摘要 |
A process for producing o- and p- substituted benzene compounds separately from a binary mixture in any proportions of said compounds. The said o- and p- substituted benzene compounds comprise isomeric 1,2 substituted benzene compound of Formula (1) and 1,4 substituted benzene compound of Formula (2) respectively, wherein R1 is selected from the group of -OH, -COOH, -NH2, N(R3)(R4) where R3 and R4 are from the group -H, (CH2)nCH3; n=0-4; and R2 is selected from the group consisting of -(CO-CH3), -(NH2), -(OH), -(NO2), -(X), -(OCH3), -COOH, -CHO, -(OCH2CH3) and X is halogen selected from F, CL, Br and I. The process basically involves (i) treating the said binary mix first with an organic solvent to phase separate by preferential solubilisation one of the said two compounds, (ii) contacting the solution phase with an ion exchange resin for preferentially adsorbing and recovering further any of said undissolved compound present to thereby further phase separate from the said compound in said solution phase the other compound as substantially pure undissolved compound, and (iii) recovering from the said solution phase of step (ii) above the said soluble compound in substantially pure form by desolventising the solution phase in conventional manner. The process provides for simple and cost effective method of producing pure compounds of Formula (1) and Formula (2) separately in high yield. |
