发明名称 |
Inhibitors of transcription factor NF-kB. |
摘要 |
The present invention provides pharmaceutical compositions of salicylanilide inhibitors of transcription factor NF-kappaB, and methods for treating diseases in which activation of NF-kappaB is implicated. More specifically, the present invention provides methods of treatment of a variety of diseases associated with NF-kappaB activation including inflammatory disorders; particularly rheumatoid arthritis, inflammatory bowel disease, and asthma; dermatosis, including psoriasis and atopic dermatitis; autoimmune diseases; tissue and organ rejection; Alzheimer's disease; stroke; atherosclerosis; restenosis; cancer, including Hodgkin's disease; certain viral infections, including AIDS; osteoarthritis; osteoporosis; and Ataxia Telangiestasia by administering to a patient in need thereof a compound of the present invention. |
申请公布号 |
ZA200007447(B) |
申请公布日期 |
2002.02.13 |
申请号 |
ZA20000007447 |
申请日期 |
2000.12.13 |
申请人 |
SMITHKLINE BEECHAM CORPORATION |
发明人 |
CALLAHAN, JAMES, FRANCIS;CHABOT-FLETCHER, MARIE, C. |
分类号 |
A61P1/00;A61K31/167;A61P9/00;A61P9/10;A61P11/06;A61P17/00;A61P17/06;A61P19/02;A61P19/10;A61P25/28;A61P29/00;A61P31/18;A61P35/00;A61P37/02;A61P37/04;A61P37/06;A61P43/00;C07C235/64 |
主分类号 |
A61P1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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