HUMAN NEUROKININ-1 RECEPTOR

摘要

Recombinant human neurokinin-1 receptor (human NK1R) is disclosed which has been prepared by polymerase chain reaction techniques. Also disclosed is the complete sequence of human NK1R complementary DNA; expression systems, including a CH0 (chinese hamster ovarian cell line) stable expression system; and an assay using the CH0 expression system. NK1R, also known as substance P receptor, can be used in an assay to identify and evaluate entities that bind substance P receptor. The assay can also be used in conjunction with diagnosis and therapy to determine the body fluid concentration of substance P in arthritis patients.