METHOD FOR MANUFACTURING CEFUROXIME

摘要

PURPOSE: Provided is a method for easily manufacturing cefuroxime in high purity and yield by manufacturing crystalline cefuroxime sodium then treating it with inorganic acid in the presence of a mixed solvent of water and organic solvent. CONSTITUTION: The cefuroxime represented by the formula(2) is manufactured by dissolving 7-amino-3-hydroxymethylcephalosphoranic acid in inorganic salt solution, in the range of pH6-7; acylating the resultant compound with 2-(fur-2yl)-2-methoxyimino acetic chloride to obtain a cephalosporin derivative of the formula(1) as an intermediate; carbamoylating hydroxy group at C-3 of the intermediate compound with isocyanate compound of the formula(4): R-NCO in the range of less than pH 1; then hydrolyzing it to obtain cefuroxime of the formula(2). In the formula(4), R is a protecting group selected from chlorosulfonyl group, trichloroacethyl group, trimethylsilyl group, bromo sulfonyl group, dichloroacethyl group, 2,2,2-trichloroethoxycarbonyl, dihalophosphinyl group and dimethoxyphosphinyl group.