METHODS FOR ENHANCING TARGETED GENE ALTERATION USING OLIGONUCLEOTIDES
摘要
Methods are presented for enhancing the efficiency of oligonucleotide-mediated repair or alteration of genetic information. The methods comprise using cells or cell-free extracts having altered levels or activity of at least one protein from the RAD52 epistasis group, the mismatch repair group or the nucleotide excision repair group. Kits and compositions are also presented.
申请公布号
WO0210364(A2)
申请公布日期
2002.02.07
申请号
WO2001US23770
申请日期
2001.07.27
申请人
UNIVERSITY OF DELAWARE;KMIEC, ERIC, B.;GAMPER, HOWARD, B.;RICE, MICHAEL, C.;LIU, LI
发明人
KMIEC, ERIC, B.;GAMPER, HOWARD, B.;RICE, MICHAEL, C.;LIU, LI