USE OF SELECTIVE ADENOSINE A1 RECEPTOR AGONISTS, ANTAGONISTSAND ALLOSTERIC ENHANCERS TO MANIPULATE ANGIOGENESIS

摘要

Angiogenesis is manipulated by administration of selective adenosine A1 allosteric enhancers can be administered in an amount effective to induce angiogenesis at a desired location for treating conditions in which increase d angiogenesis is desired, such as stroke, heart disease, and peripheral vascular disease. Selective A1 antagonists can be administered in an amount effective to inhibit angiogenesis at a desired location for treating conditions in which decreased angiogenesis is desired, such as for treating tumors, diabetic retinopathy, inflammatory diseases such as rheumatoid arthritis and psoriasis.