16ALPHA-METHYL OR ETHYL SUBSTITUTED ESTROGENS

摘要

The invention makes a 16.alpha.-substituted steroidal compound available having formula 1, wherein the dotted ring is a fully saturated, a fully aromatic or a saturated ring with a .DELTA.5-10 double bond; R1 is (C1- C3)alkyl or (C2-C3)alkenyl, and each of these groups can be substituted with one or more halogens; R2 is (C1-C4)alkyl, (C2-C4)alkenyl or methylene, and each of these groups can be substituted with one or more halogens; R3 is methyl or ethyl; or a prodrug thereof, which compound can be used for an estrogen receptor .alpha. selective treatment.