发明名称 |
HEPARIN-LIKE COMPOUNDS, THEIR PREPARATION AND USE TO PREVENT ARTERIAL THROMBSIS ASSOCIATED WITH VASCULAR INJURY AND INTERVETIONS |
摘要 |
The present invention is related to heparin-like compounds characterized by their capacity of inhibiting collagen-induced platelet aggregation in flowing whole blood and their use for prophylactic treatment of arterial thrombosis associated with vascular or microvascular injury and interventions. Said properties are related to a high coupling density of negatively charged heparin or heparin-like glycosaminoglycan molecules, present in multiple heparin or heparin-like glycosaminoglycans as well as in proteoglycans containing said multiple heparin or heparin-like glycosaminoglycans or lower-molecular-weight heparin or heparin-like glycosaminoglycans connected directly or through spacer/linker molecules to globular core molecules. Heparin-like compounds, with said properties are obtainable from mammalian mast cells, by tissue extraction or cell cultivation. The heparin-like compounds of the present invention can also be produced by synthetical, semisynthetical and/or biotechnological methods and they are useful for manufacturing preparations, means and devices for local or topical application in prophylactic treatment of arterial thrombosis and its sequelae.
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申请公布号 |
US2002016308(A1) |
申请公布日期 |
2002.02.07 |
申请号 |
US19990230097 |
申请日期 |
1999.01.20 |
申请人 |
LASSILA RIITTA;KOVANEN PETRI;LINDSTEDT KEN |
发明人 |
LASSILA RIITTA;KOVANEN PETRI;LINDSTEDT KEN |
分类号 |
A61L33/10;A61K31/727;A61L33/00;A61L33/08;A61P7/02;C08B37/00;C08B37/10;(IPC1-7):A61K31/24;A61K31/715;C07H1/00 |
主分类号 |
A61L33/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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