发明名称 |
Process for the preparation of the mesylate salt trihydrate of 1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol and intermediates useful therefor |
摘要 |
The present invention is directed to a novel process for the preparation of the mesylate trihydrate of the compound of formula (I), (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol: The present invention is further directed to a process for the preparation of a (2S)-(+)-compound of formula (II): wherein R1 is a protecting group. In addition, the present invention relates to intermediates useful in said processes.
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申请公布号 |
US2002016466(A1) |
申请公布日期 |
2002.02.07 |
申请号 |
US20010840668 |
申请日期 |
2001.04.23 |
申请人 |
WALINSKY STANLEY WALTER;SINAY TERRY GENE;RAINVILLE JOSEPH PHILIP |
发明人 |
WALINSKY STANLEY WALTER;SINAY TERRY GENE;RAINVILLE JOSEPH PHILIP |
分类号 |
C07B61/00;C07D211/52;(IPC1-7):C07D211/52 |
主分类号 |
C07B61/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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