发明名称 Terminally-branched polymeric linkers containing extension moieties and polymeric conjugates containing the same
摘要 E1a-3a are independently selected from the group consisting of hydrogen, C1-6 alkyls, C3-12 branched alkyls, C3-8 cycloalkyls, C1-6 substituted alkyls, C3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C1-6 heteroalkyls, substituted C1-6 heteroalkyls, C1-6 alkoxy, phenoxy, C1-6heteroalkoxy, wherein B1 is a leaving group, OH, a residue of a hydroxyl-containing moiety or a residue of an amine-containing moiety or wherein E6 is independently selected from the same group which defines wherein E1b-3b are independently selected from the group consisting of hydrogen, C1-6 alkyls, C3-12 branched alkyls, C3-8 cycloalkyls, C1-6 substituted alkyls, C3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C1-6 heteroalkyls, substituted C1-6 heteroalkyls, C1-6 alkoxy, phenoxy, C1-6 heteroalkoxy, wherein B2 is a leaving group, OH, a residue of a hydroxyl-containing moiety or a residue of an amine-containing moiety; G is a polymeric residue; Y1-3, Y2a-d and Y3a-d are each independently O, S or NR11a M1-4, M2a-2d, M3a-3d, and M4a-4d are each independently O, S or NR11b; M5 and M5a-d are each independently X or Q, wherein X is an electron withdrawing group and Q is a moiety containing a free electron pair positioned three to six atoms from C(=Y3) or C(=Y3a-d); R1-10, R1a-11a, R1b-11b, R1c-10c and R1d-10d are each independently selected from the group consisting of hydrogen, C1-6 alkyls, C3-12 branched alkyls, C3-8 cycloalkyls, C1-6 substituted alkyls, C3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C1-6 heteroalkyls, substituted C1-6 heteroalkyls, C1-6 alkoxy, phenoxy and C1-6 heteroalkoxy; and a, b, c, d1-d6, e1-e6, f1-f6, g1-g6, h1-h6, i1-i6, j1-j6, k1-k6, l1-l6, m1-m6 are each independently zero or a positive integer.
申请公布号 US2002015691(A1) 申请公布日期 2002.02.07
申请号 US20010823296 申请日期 2001.03.29
申请人 GREENWALD RICHARD B.;CHOE YUN H. 发明人 GREENWALD RICHARD B.;CHOE YUN H.
分类号 C08G73/02;(IPC1-7):A61K31/785;C08G73/00 主分类号 C08G73/02
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