| 摘要 |
<p>The present invention relates to new biocompatible polymer derivatives, and a protein-polymer or a peptide-polymer which is produced by conjugation of biologically active protein and peptide with the biocompatible polymer derivatives. More particularly, the present invention relates to a highly reactive branched biocompatible polymer derivative containing a long linker between polymer derivatives and protein or peptide molecules, which is minimized in decrease the biological activity of proteins by conjugating the less number of polymer derivatives to the active sites of proteins, improved in water solubility, and protected from being degraded by protease. In hence, the highly reactive branched biocompatible polymer-proteins or peptides conjugates with long linker retain the biological activity in a long period of time and improve a bioavailability of bioactive proteins and peptides.</p> |
