发明名称 |
SINGLE CHAIN ANTIBODY AGAINST MUTANT p53 |
摘要 |
More than 90 % of mutations found in the p53 protein produce a conformational change in p53 which results in the exposure of an epitope, which is otherwise hidden in the hydrophobic core of the molecule. A single chain antibody (scFv) which specifically recognizes this common mutant epitope in mutant p53 but not in wild type p53 is disclosed. Also described are a DNA molecule encoding the scFv, pharmaceutical compositions comprising the antibody and their use in methods of treatment.
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申请公布号 |
WO0168801(A3) |
申请公布日期 |
2002.02.07 |
申请号 |
WO2001IL00225 |
申请日期 |
2001.03.09 |
申请人 |
RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH AND INDUSTRIAL DEVELOPMENT LTD.;SOLOMON, BEKA;COHEN, GERALD;GOVORKO, DIMITRI |
发明人 |
SOLOMON, BEKA;COHEN, GERALD;GOVORKO, DIMITRI |
分类号 |
C07K16/18;C12P21/08;(IPC1-7):C07H21/02;C07H21/04;C12N15/00;C12N15/09;C12N15/63;C12N15/70;C12N15/74;C12N5/00;C12N5/02;C12P21/06;C07K16/00 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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