DEMENTIA REMEDIES CONTAINING 2-ARYL-8-OXODIHYDROPURINE DERIVATIVES AS THE ACTIVE INGREDIENT

摘要

Medicines for treatment or prevention of dementia containing as the active ingredient 2-aryl-8-oxodihydropurine derivatives of the general formula (I) or pharmaceutically acceptable acid addition salts thereof: (I) [wherein W is H, C1-6 alkyl, halogeno, C1-6 alkoxy, or the like; X is H, C1-6 alkyl, a group of the general formula (Q): -CH(R<3>)CON(R<1>)(R<2>) (wherein R<1> is C1-6 alkyl or the like; R<2> is phenyl-substituted C1-4 alkyl or the like; and R<3> is H or the like), or the like; Y is H, C1-6 alkyl, a group of the above general formula (Q), or the like; and A is substituted phenyl or the like, with the proviso that one of X and Y is a group of the general formula (Q) and the other is a group selected from among those described above for X or Y except those of the general formula (Q).] The above compounds exhibit an extremely potent ameliorative effect on learning disorder and/or memory disorder and thus are useful in the treatment or prevention of Alzheimer-type dementia, cerebrovascular dementia, senile dementia, and so on.