| 发明名称 |
IMIDAZO-PYRAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS |
| 摘要 |
A class of imidazo[1,2-.alpha.]pyrazine analogues substituted in the 3- position by a substituted phenyl ring, being selective ligands for GABAA receptors which interact more favourably with the .alpha.2 and/or .alpha.3 subunit than with the .alpha.1 subunit, are accordingly of benefit in the treatment and/or prevention of a variety of disorders of the central nervous system, including anxiety and convulsions, with a reduced propensity to caus e sedation.
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| 申请公布号 |
CA2417121(A1) |
申请公布日期 |
2002.02.07 |
| 申请号 |
CA20012417121 |
申请日期 |
2001.07.18 |
| 申请人 |
MERCK SHARP & DOHME LIMITED |
发明人 |
STREET, LESLIE JOSEPH;HALLETT, DAVID JAMES;GOODACRE, SIMON CHARLES |
| 分类号 |
A61K31/4985;A61P25/08;A61P25/22;A61P25/28;C07B61/00;C07D487/04;(IPC1-7):C07D487/04;C07D235/00;C07D241/00;A61K31/415;A61K31/495 |
主分类号 |
A61K31/4985 |
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