发明名称 |
Method for enhancing outflow of aqueous humor in treatment of glaucoma |
摘要 |
Elevated intra-ocular pressure is reduced by administration directly to the eye of compounds that inhibit function of a Na+-K+-2Cl-2 cotransporter mechanism discovered in trabecular meshwork cells of mammalian eyes. These compounds are useful in treatment of diseases of the eye associated with elevated intra-ocular pressure, such as ocular hypertension and glaucoma. A screening method is provided to discover additional compounds with utility for lowering intra-ocular pressure by substantially inhibiting the Na+-K+-Cl-2 cotransporter mechanism in trabecular meshwork cells.
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申请公布号 |
US2002016346(A1) |
申请公布日期 |
2002.02.07 |
申请号 |
US20010785860 |
申请日期 |
2001.02.16 |
申请人 |
THE REGENTS UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION |
发明人 |
BRANDT JAMES D.;O'DONNELL MARTHA E.;CURRY FITZ-ROY E. |
分类号 |
A61K31/00;A61K31/196;A61K31/341;A61K31/402;A61K31/44;(IPC1-7):A61K49/00;C12Q1/00 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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