发明名称 |
GENE EXPRESSION PROFILE FOR KSHV INFECTION AND METHODS FOR TREATING SAME |
摘要 |
The present invention utilizes nucleic acid microarray technology to identify changes in the host endothelial cell transcription pattern that occurs during the latent and lytic phase of the KSHV life cycle. The production or activity of some genes up regulated during the lytic cycle were subsequently inhibited, and two such targets were shown to have a role in expression of late viral genes. Using this combined approach we have identified cellular pathways previously unknown to be important for KSHV infection, and present evidence for the efficiency of the novel antiviral approaches thus discovered. In addition, the present invention identifies a wide variety of endothelial cells genes and pathways that are involved in a variety of endothelial cell-mediated activity, including angiogenesis and transformation. |
申请公布号 |
WO0210339(A2) |
申请公布日期 |
2002.02.07 |
申请号 |
WO2001US24469 |
申请日期 |
2001.08.01 |
申请人 |
ORTHO-MCNEIL PHARMACEUTICAL, INC.;OREGON HEALTH & SCIENCE UNIVERSITY |
发明人 |
LUUKKONEN, MATTIAS;MOSES, ASHLEE;FRUEH, KLAUS;NELSON, JAY;BELL, YOLANDA;HEINRICH, MICHAEL;SIMMEN, KENNETH |
分类号 |
G01N33/53;A61K31/00;A61K31/07;A61K31/337;A61K31/704;A61K38/21;A61K45/00;A61K45/06;A61P31/22;C12M1/00;C12N15/09;C12Q1/02;C12Q1/68;G01N21/77;G01N21/78;G01N33/58;G01N37/00 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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