发明名称 |
SPECIFIC BINDING AGENTS FOR KSHV vIL-6 THAT NEUTRALIZE A BIOLOGICAL ACTIVITY |
摘要 |
A specific binding agent is provided, wherein the specific binding agent specifically binds Kaposi's sarcoma-associated herpesvirus (KSHV) interleukin-6 (vIL-6), and the specific binding agent neutralizes an activity of vIL-6. In one embodiment, the specific binding agent is an antibody. Methods are provided for using a specific binding agent that binds vIL-6, and neutralizes a biological activity of vIL-6. Methods of treatment for a KSHV-associated disorder are provided, as are kits that include a specific binding agent of the invention. A method is also provided for testing an agent for effectiveness in treating a KSHV-associated disorder. The method for effectiveness the agent with a cell free system comprising a vIL-6 receptor component and vIL-6, and comparing the binding of vIL-6 and the receptor component in the presence of the agent to binding of vIL-6 to receptor component in the absence of the agent. A decrease in the binding of vIL-6 to the receptor component in the presence of the agent indicates that the agent is effective for treating the KSHV-associated disorder. |
申请公布号 |
WO0210764(A2) |
申请公布日期 |
2002.02.07 |
申请号 |
WO2001US24179 |
申请日期 |
2001.07.31 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES, THE NATIONAL INSTITUTES OF HEALTH;AOKI, YOSHIYASU;TOSATO, GIOVANNA |
发明人 |
AOKI, YOSHIYASU;TOSATO, GIOVANNA |
分类号 |
A61P31/20;A61P35/00;C07K16/08;C07K16/24;C12Q1/70;G01N33/569;G01N33/68 |
主分类号 |
A61P31/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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