| 摘要 |
<p>The current invention provides novel methods for stimulating the polymerization of tau protein by altering oxidative conditions for the polymerization reaction and/or by altering the oxidative state of a fatty acid used to stimulate the polymerization reaction. The current invention provides a method for screening reagents for the ability to effect tau polymerization using the novel methods of the invention for inducing tau polymerization. Finally, the current invention provides methods for regulating the assembly of tau protein in the brain of mammals in need of such regulation, by administering to the mammal, an effect amount of an inhibitor of fatty acid oxidation.</p> |
