发明名称 |
BIOABSORBABLE COMPOSITES OF DERIVATIZED HYALURONIC ACID |
摘要 |
The present invention relates to a composite and a method for reducing post-operative adhesion of tissues. The composite includes a biocompatible, biodegradable support, and a water-insoluble hyaluronic acid derivative at the support. The hyaluronic acid derivative includes an N-acylurea that results from cross-linking by the reaction of hyaluronic acid with a multifunctional carbodiimide. Optionally, a monocarbodiimide also may be employed. A pharmaceutically-active molecule may be added to the N-acylurea derivative of hyaluronic acid. Although the composite includes material that prevents adhesion between tissues, in order to reduce the need for suturing when the composite is being used during a surgical procedure, a material that enhances adhesion of the composite to tissues may be applied to a surface of the composite. A method of forming the composite for reducing post-operative adhesion of tissues, including the step of applying an N-acylurea derivative of hyaluronic acid resulting from cross-linking with a multifunctional carbodiimide, to a biocompatible, biodegradable support; a method of preparing a drug delivery vehicle that includes a pharmaceutically-active molecule with the N-acylurea derivative of hyaluronic acid resulting from cross-linking with a multifunctional carbodiimide; and a method of reducing post-operative adhesion of tissues are disclosed.
|
申请公布号 |
WO0209792(A1) |
申请公布日期 |
2002.02.07 |
申请号 |
WO2001US40794 |
申请日期 |
2001.05.22 |
申请人 |
ANIKA THERAPEUTICS, INC. |
发明人 |
SADOZAI, KHALID, K.;KUO, JING-WEN;SHERWOOD, CHARLES, H. |
分类号 |
A61K47/48;A61L31/10;A61L31/12;A61L31/14;A61L31/16;C08B37/08;(IPC1-7):A61L31/12;A61K47/36;C08B37/00 |
主分类号 |
A61K47/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|