| 摘要 |
The compositions described herein allow for the delivery of substances to the organs of the skin such as hair follicles and sebaceous glands, to the tissues under the skin such as muscles, joints and related tissues and to the systemic circulation. The compositions can be used to treat a variety of skin disorders as well as disorders of deeper tissue or disorder distant to the site of application through absorption through the skin. The formulations include pharmaceutical compositions with or without enhancers for delivery of active ingredients to the skin and organs of the skin to treat common disorders of the skin and its organs, as well as areas distant from the skin, i.e., regional or systemic delivery via transdermal administration. Preferred enhancers combine a diol and a cell-envelope disrupting agent. Examples of dermatologic conditions which can be treated include sunburn prevention and treatment, minor and major burns, agents toxic to the skin such as poison ivy, chemical and non-chemical such as radiation that disrupt the normal epidermis, conditions of the skin organs such as hirsutism, acne, infections such as bacterial and viral infection, inflammatory processes such as after application of facial peels, lasers, tanning agents, drug reactions, muscular and joint inflammation and pain such as arthritis and sports injuries, hormone deficiencies, menopause, and contraception.
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