发明名称 |
CHIMERIC OLIGOMERS HAVING AN RNA-CLEAVAGE ACTIVITY |
摘要 |
<p>New chimeric oligomers having an RNA-cleavage activity, as well as their use for cleaving RNA-substrates in vitro and in vivo have been disclosed. The new chimeric oligomers contain an active centre, the building blocks of which are selected from nucleotides or/and nucleotide analogues, as well as flanking regions contributing to the formation of a specific hybridization of the oligomer with an RNA-substrate and containing at least one building block which is different from deoxyribonucleotides and ribonucleotides.</p> |
申请公布号 |
EP0866865(B1) |
申请公布日期 |
2002.02.06 |
申请号 |
EP19960938213 |
申请日期 |
1996.11.14 |
申请人 |
VIMRX HOLDINGS, LTD. |
发明人 |
LUDWIG, JANOS;SPROAT, BRIAN |
分类号 |
C12N15/09;A61K31/00;A61K31/70;A61K31/7088;A61K38/00;A61K48/00;A61P9/00;A61P9/12;A61P17/00;A61P17/06;A61P31/00;A61P31/14;A61P35/00;A61P37/00;C07H21/02;C12N9/00;C12N15/113;C12N15/52;C12Q1/68;(IPC1-7):C12N15/52;C12N15/11 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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