发明名称 |
Method for producing human hemoglobin proteins using plant cells |
摘要 |
A method for producing human hemoglobin proteins by (i) inserting into plant cells one or more nucleic acid molecules that each comprise at least one sequence coding for a protein component of a human hemoglobin protein capable of reversibly binding oxygen, and optionally a sequence coding for a selection agent; (ii) selecting cells containing nucleic acid coding for the protein component of the human hemoglobin protein; (iii) optionally propagating the transformed cells either in a culture or by regenerating whole transgenic or chimeric plants; and (iv) recovering and optionally purifying the human hemoglobin protein that includes a complex consisting of the protein or proteins coded for by the nucleic acid and at least one iron-containing polphyritic nucleus, or a plurality of such complexes.
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申请公布号 |
US6344600(B1) |
申请公布日期 |
2002.02.05 |
申请号 |
US19980983564 |
申请日期 |
1998.06.09 |
申请人 |
MERISTEM THERAPEUTICS;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE |
发明人 |
MEROT BERTRAND;DIERYCK WILFRID;LENEE PHILIPPE;MARDEN MICHAEL;GRUBER VERONIQUE;PAGNIER RENEE-JOSEE;BAUDINO SYLVIE;POYART CLAUDE |
分类号 |
A61K38/00;C07K14/805;C12N15/12;C12N15/82;(IPC1-7):A01H5/00;C12N15/05 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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