发明名称 |
The protein kinase domain of the large subunit of herpes simplex type 2 ribonucleotide reductase (icp10pk) has anti-apoptopic activity |
摘要 |
The invention relates to a method of treating neuronal apoptosis in a mammal using nucleic acid encoding HSV-2 ICP10PK, or a polypeptide encoded thereby. The invention further relates to a method of treating neuronal apoptosis in a mammal using ICP10PK in combination with a nucleic acid encoding bcl-2, or the polypeptide encoded thereby. The invention also relates to the use of ICP10PK and ICP10PK in combination with bcl-2 to treat non-neuronal diseases characterized by apoptosis. |
申请公布号 |
AU8298601(A) |
申请公布日期 |
2002.02.05 |
申请号 |
AU20010082986 |
申请日期 |
2001.07.26 |
申请人 |
UNIVERSITY OF MARYLAND, BALTIMORE |
发明人 |
LAURE AURELIAN;DANA PERKINS;CYNTHIA SMITH |
分类号 |
A61K38/16;A61K38/17;A61K48/00;C12N15/869 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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