| 摘要 |
The invention provides isolated nucleic acid molecules, designated METH-1 nucleic acid molecules, which encode novel methyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing METH-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a METH-1 gene has been introduced or disrupted. The invention still further provides isolated METH-1 proteins, fusion proteins, antigenic peptides and anti-METH-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided. |
