| 发明名称 |
INHIBITORS OF IMPDH ENZYME |
| 摘要 |
<p>The present invention relates to compounds which inhibit JMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting JMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of I1VIPDH using the compounds of this invention and related compounds.</p> |
| 申请公布号 |
SK13332001(A3) |
申请公布日期 |
2002.02.05 |
| 申请号 |
SK20010001333 |
申请日期 |
2000.03.17 |
| 申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
STAMOS DEAN;TRUDEAU MARTIN;BETHIEL SCOTT;BADIA MICHAEL;SAUNDERS JEFFREY |
| 分类号 |
C07D307/20;A61K31/27;A61K31/275;A61K31/341;A61K31/421;A61K31/422;A61K31/454;A61K31/5377;A61K31/541;A61K45/00;A61P1/18;A61P9/10;A61P11/06;A61P19/02;A61P29/00;A61P31/12;A61P35/00;A61P37/02;A61P43/00;C07C275/40;C07C275/42;C07D263/32;C07D413/12;C07D417/12;C07F9/653;(IPC1-7):A61K31/421;A61K31/277;C07C275/34 |
主分类号 |
C07D307/20 |
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