| 发明名称 |
Lactam compounds and their use as inhibitors of serine proteases and method |
| 摘要 |
Lactam inhibitors are provided which have the structureX iswhereinY is O or S and R4 is R7O- or R8and R1, R2, R3, R5, R6, R7, and R8, are as defined herein. These compounds are inhibitors of Factor Xa and thus are useful as anticoagulants, and are inhibitors of tryptase and thus are useful in treating asthma. Methods for treating cardiovascular diseases associated with thromboses and for treating asthma and related diseases are also provided.
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| 申请公布号 |
US6344450(B1) |
申请公布日期 |
2002.02.05 |
| 申请号 |
US20000633751 |
申请日期 |
2000.08.07 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
BISACCHI GREGORY S.;SEILER STEVEN M.;LAWRENCE R. MICHAEL;SUTTON, JR. JAMES C.;SLUSARCHYK WILLIAM A.;ZHAO GUOHUA |
| 分类号 |
C07D223/12;A61K31/55;A61K38/00;A61K45/00;A61K45/06;A61P1/00;A61P1/04;A61P1/16;A61P7/02;A61P9/00;A61P9/10;A61P11/00;A61P11/02;A61P11/06;A61P17/00;A61P17/06;A61P19/02;A61P25/00;A61P27/02;A61P29/00;A61P35/00;A61P37/08;A61P43/00;C07D223/10;C07D401/12;C07D401/14;C07D403/12;C07D405/12;C07D409/12;C07D413/12;C07D417/12;C07D417/14;C07K5/06;C07K5/078;(IPC1-7):A61K31/55 |
主分类号 |
C07D223/12 |
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