| 摘要 |
The following compounds are inhibitors of farnesyl protein transferase, and may be used in a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. (+)-4-(3-Bromo-8, 10-dichloro-6,11-dihydro-5H- benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(methylsulfonyl) piperidine (+)-4-(3-Bromo-8, 10-dichloro-6,11-dihydro-5H- benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N,N-dimethyl-1-piperidinesulfonamide (+)-4-(3-Bromo-8, 10-dichloro-6,11-dihydro-5H- benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(aminosulfonyl) piperidine (+)-4-(3,10-Dibromo-8-chloro-11-dihydro-5H- benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(methylsulfonyl) piperidine (+)-4-(3,10-Dibromo-8-chloro-11-dihydro-5H- benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(ethylsulfonyl) piperidine (+)-4-(3,10-Dibromo-8-chloro-1 1-dihydro-5H- benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1 -(propylsulfonyl) piperidine (+)-4-(3,10-Dibromo-8-chloro-11-dihydro-5H- benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(isopropylsulfonyl) piperidine (+)-4-(3,10-Dibromo-8-chloro-11 -dihydro-5H-benzo[5,6]cyclohepta[1,2- b]pyridin-11-yl)-1 -(butylsulfonyl) piperidine (+)-4-(3,10-Dibromo-8-chloro-11-dihydro-5H-benzo[5,6]cyclohepta[1,2- b]pyridin-11-yl)-1-(trifluoromethyl sulfonyl) piperidine (+)-4-(3,10-Dibromo-8-chloro-11-dihydro-5H- benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(trifluoroethyl sulfonyl) piperidine (+)-4-(3,10-Dibromo-8-chloro-11-dihydro-5H- benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-(vinylsulfonyl) piperidine (+)-4-(3,10-Dibromo-8-chloro-6, 11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11 (R)-yl)-1-(phenylsulfonyl) piperidine (+)-4-(3,10-Dibromo-8-chloro-6,11-dihydro-5H- benzo[5,6]cyclohepta[1,2-b]pyridin-11 (R)-yl)-1-[(1-methyl-1H-imidazol-4yl)sulfonyl] piperidine; and (+)-4-(3, 10-Dibromo-8-chloro-6, 11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11 (R)-yl)-1-[(5-(3-isoxazolyl)-2-thienylsulfonyl] piperidine
|
