STREPTOGRAMINE DERIVATIVES, PREPARATION OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

摘要

PCT No. PCT/FR95/01025 Sec. 371 Date Jan. 31, 1997 Sec. 102(e) Date Jan. 31, 1997 PCT Filed Jul. 31, 1995 PCT Pub. No. WO96/04299 PCT Pub. Date Feb. 15, 1996Streptogramine derivatives of general formula (I) below, wherein the radical R1 is a methyl or ethyl radical, the radical R2 is a bromine or chlorine atom, or is an alkenyl radical with 3 to 5 carbon atoms when R3 and R4 are methyl, and one of R3 and R4 is a hydrogen atom or a methyl radical and the other is a methyl radical are disclosed. The streptogramine derivatives of general formula (I) have particularly useful antibacterial properties, and may be used in combination with a pristinamycin II derivative.