MODIFIED VIRUS HAVING AN ALTERED TROPISM

摘要

The present invention describes a modified virus comprising one or more non- native polypeptides, which polypeptide comprises one or more framework moieties each containing one or more biding moieties, which polypeptides is capable of being expressed in the cytoplasm and nucleus of a mammalian host cell in a conformation which is maintained in the absence of a ligand for sa id binding moieties, said conformation allowing said binding moieties subsequently to bind with said ligand, and which polypeptide is capable of transport through the nuclear membrane, wherein said modified virus has an altered tropism conferred by said binding moieties and the use of such virus es in the therapy, particularly in the treatment of tumours or other cancerous cells.