MU-CONOPEPTIDES

摘要

The present invention is to .mu.-conopeptides, derivatives or pharmaceutical ly acceptable salts thereof. The present invention is further directed to the u se of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated sodium channels. Thus, the .mu.-conopeptides or derivatives are useful as neuromuscular blocking agents, local anesthetic agents, analgesic agents and neuroprotective agents. The .mu.-conopeptides are also useful for treating neuromuscular disorders. The invention is further directed to nucleic acid sequences encoding the .mu.-conopeptides and encoding propeptides, as well a s the propeptides.