发明名称 |
Methods for producing enantiomerically pure alpha-substituted carboxylic acids |
摘要 |
In accordance with the present invention there are provided methods for producing enantiomerically pure alpha-substituted carboxylic acids, such as, for example, alpha-amino acids and alpha-hydroxy acids, said method comprising combining an aldehyde or ketone with a cyanide and ammonia or an ammonium salt or an amine, in the presence of a nitrilase or a polypeptide having nitrilase activity which stereoselectively hydrolyzes the amino nitrile or cyanohydrin intermediate under conditions sufficient to produce the carboxylic acid.
|
申请公布号 |
US2002012974(A1) |
申请公布日期 |
2002.01.31 |
申请号 |
US20000751299 |
申请日期 |
2000.12.28 |
申请人 |
MADDEN MARK;WEINER DAVID PAUL;CHAPLIN JENNIFER ANN |
发明人 |
MADDEN MARK;WEINER DAVID PAUL;CHAPLIN JENNIFER ANN |
分类号 |
C12N15/09;C07C229/36;C12N9/78;C12P7/42;C12P13/04;C12P13/06;C12P13/22;C12P41/00;(IPC1-7):C12N9/14;C07H21/04 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|