发明名称 |
APPLICATIONS WITH AND METHODS FOR PRODUCING SELECTED INTERSTRAND CROSS-LINKS IN NUCLEIC ACIDS |
摘要 |
The Invention relates to a method for providing at least one selected sequence in a nucleic acid with interstrand cross-links. The method comprises hybridizing at least one selected single strand sequence with a complementary single strand nucleic acid or a functional analogue thereof. The selected sequence or complementary nucleic acid or both comprise a cross-linking agent. The invention also relates to a method, referred to as COBRA, for the labeling of a set of at least two bio-organic molecules with a set of at least two colors, comprising generating said set of colors through combining ratio labeling with binary labeling.
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申请公布号 |
US2002012915(A1) |
申请公布日期 |
2002.01.31 |
申请号 |
US19990454404 |
申请日期 |
1999.12.03 |
申请人 |
VOLKERS HERMAN;HEETEBRIJ ROBERT;HOUTHOFF HENDRIK-JAN;VAN GIJLSWIJK R.P.M.;TANKE HENDRIKUS JOHANNES;RAAP ANTON KLAAS |
发明人 |
VOLKERS HERMAN;HEETEBRIJ ROBERT;HOUTHOFF HENDRIK-JAN;VAN GIJLSWIJK R.P.M.;TANKE HENDRIKUS JOHANNES;RAAP ANTON KLAAS |
分类号 |
G01N33/50;C07K1/13;C12N15/09;C12Q1/68;G01N33/53;G01N33/566;G01N33/58;(IPC1-7):C12Q1/68;C12P19/34 |
主分类号 |
G01N33/50 |
代理机构 |
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